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Long-acting non-sedating injectable calmative agent.
Composition
Contains: Reserpine 0.5 mg/mL
Features and Benefits
RAKELIN causes a rapid release of the nerve system transmitters norepinephrine and serotonin from bound stores in the brain, subjecting them to rapid destruction by the body?¢‚Ǩ‚Ñ¢s own enzyme, monoamine oxidase (MOA). While ?¢‚Ǩ?ìbound?¢‚Ǩ? the stores are not available to MOA. Norepinephrine and serotonin have potent effects on the metabolism of the brain. High levels (especially of norepinephrine) cause stimulation of cerebral activity and anxiety. Lowered levels depress cerebral activity resulting in relaxation and calmness. Norepinephrine and serotonin, on release from the bound stores, undergo rapid destruction by MOA. The net depletion of these substances creates the calming
and relaxing effects of RAKELIN. These effects continue for many days after administration, because levels are restored only slowly.
Indications
RAKELIN is particularly indicated where a prolonged effect to calm horses and reduce anxiety states is required, especially in the handling and management of dangerously anxious horses. Useful as an aid when unfamiliar surroundings and/or unaccustomed stress create anxiety in horses, and as a calming agent to aid in the
training and education of stressed young horses.
RAKELIN produces a prolonged calming effect without sedation, drowsiness, or loss of coordination, and
vicious or dangerously anxious horses will become relaxed, sociable and co-operative with continued treatment.
RAKELIN is indicated in any situation where stress/anxiety in horses is difficult to manage. Before using on horses that will be involved in competitive activities, the pre-competition withdrawal period should be ascertained (this may vary from one country to another depending on laboratory methods used for substance detection).
Dosage and Administration
Give RAKELIN by intramuscular injection only. The dose administered must be sufficient to deplete Norepinephrine and Serotonin stores. Because the initial levels of these stores will vary from horse to horse, the
veterinarian must be prepared to vary the dose to achieve optimum efficacy. A useful clinical sign is the brief
period of diarrhoea which accompanies the initial release of bound Serotonin before its destruction by MOA.
This period of increased bowel activity is a reliable indicator that the desired behavioural response should
follow.
Adult Horses:
1 - 4 mL weekly, or as directed by a veterinary surgeon. Give by intramuscular injection only.
Some veterinarians advise giving 2 - 4 ml on alternate days until desired response is achieved.
Then repeat injections of 2 - 4 mL at 4 - 8 day intervals. This dosage regime may be altered to
suit the individual animal response. Lack of response is almost always the result of underdosing.
Warnings:
RAKELIN may produce penile relaxation. Stallions which have been
treated with RAKELIN should not be used to serve mares for at least
14 days following injection.
Presentation
20mL sterile glass multi-dose vial for intramuscular injection
Storage
Store below 25oC (air conditioning). Protect from light.
Poisons Schedule
S4
APVMA Approval Number
51452
General Notes
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