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Non-Steroidal Anti-Inflammatory Drug (NSAID)
Composition
Contains: Ketoprofen 100 mg/mL
Features and Benefits
Ketoprofen is a non-steroidal anti-inflammatory agent which inhibits
both the cyclo-oxygenase and lypoxygenase pathways of arachidonic
acid breakdown. It is a potent, non-narcotic analgesic and anti-pyretic
agent in the horse. Ketoprofen is a propionic acid derivative.
Indications
General: suppression of untoward inflammatory reactions and
associated pain and fever.
Ophthalmology: Ketoprofen is particularly effective in controlling
ophthalmic inflammation because of its dual inhibition of
cyclo-oxygenase and lipoxygenase pathways of arachidonic
acid breakdown. Traumatic corneal ulcers, keratitis, anterior
and posterior uveitis, and orbital trauma.
Musculo-skeletal:Traumatic joint and connective tissue disease,
osteoarthritis, exertional myopathy, tenosynovitis, tendon and
ligament sprains.
Surgery: Post-surgical inflammation and pain control. Used pre-surgery,
Ketoprofen assists in control of peri-operative pain.
Colic: Ketoprofen is less toxic than, and of equal efficacy to, Flunixin,
in the management of equine colic. Ketoprofen should be used
in colic cases where surgery is not required, or is not an available
option. Continuous patient evaluation should always be maintained in cases of equine colic, as druginduced analgesia may mask clinical signs which indicate a need for surgical intervention. The analgesic effect of Ketoprofen is evident within 15 minutes of intravenous administration.
Dosage and Administration
Horse: 2 mg/kg (2 ml/100 kg bodyweight) once daily by slow intravenous or intramuscular injection. It is readily and rapidly absorbed by the intramuscular route and is almost totally bound to plasma albumin in the horse.
It is widely distributed in tissues, including the eye and synovial fluid. Ketoprofen has a half-life of one hour in the horse, and repeated administration does lead to accumulation in animals with normal hepatic and renal function.
Cattle: 3 mg/kg by intramuscular or intravenous injection once daily for up to 3 days.
Ketoprofen possesses a wide therapeutic index: injections of 25 times the therapeutic dose are needed to produce acute toxicity. Trials have indicated that Ketoprofen has a wider safety margin, and lower toxicity potential, than both phenylbutazone and flunixin meglumine in the horse (assessed on incidence of gastro-intestinal ulceration and renal
disease after administration).
Warnings:
Ketoprofen should not be used in cases with pre-existing gastro-intestinal ulceration or severe renal insufficiency. The safety of Ketoprofen is not established in the pregnant mare. Take care when using Ketoprofen with other drugs which can have renal side effects, such as gentamicin.
All NSAIDs have the potential to produce side effects such as gastro-intestinal irritation and ulceration.
Avoid perivascular administration.
Presentation
50 mL sterile multi-dose glass vial
Storage
Store below 30o C (room temperature). Protect from light.
Poisons Schedule
S4
APVMA Approval Number
40312
General Notes
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