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Broad spectrum gentamicin antibiotic
Composition
Contains: Gentamicin 100 mg/mL (as the sulfate)
Features and Benefits
Gentamicin is an aminoglycoside antibiotic which is bactericidal by inhibiting
protein synthesis in susceptible bacteria. Gentamicin is not significantly bound
by animal protein and hence provides useful concentrations in peritoneal and
pleural fluids. Its clearance rates may be reduced in cases of renal impairment,
and prolonged courses are considered to be potentially nephrotoxic.
Gentamicin should only be used when the target bacterial species is known to
be sensitive to this antibiotic.
Gentamicin is effective against a range of gram negative bacteria including:
actinobacillus spp, klebsiella spp, bordetella bronchiseptica, enterobacter spp,
pseudomonas spp, e.coli.
Indications
Gentamicin is indicated in infections in horses, dogs and cats which are known to
be responsive to Gentamicin.
GENTAMICIN is rapidly absorbed following parenteral administration but reaches only low
concentrations in the CSF and eye. Peak serum concentrations are reached within 30 - 60 minutes
after intramuscular injection. Therapeutic plasma concentrations are maintained in the horse for up to 6
hours following intramuscular injection. Gentamicin crosses the placenta. Excretion is primarily by by
glomerular filtration.
Because of its rapid absorption after administration, and rapid bactericidal action, Gentamicin is
particularly useful in acute infections, particularly of the urinary tract, reproductive tract and respiratory
system.
Warning!
Administration should not exceed 5 days. Do not use in animals with impaired renal function.
Avoid using Gentamax in small cats and dogs as there is a risk of overdosing due to the very small
injection volumes required. Use only in situations where sensitivity indicates that there is no
suitable alternative antibiotic. Do not use in pregnant animals, as gentamicin crosses the
placenta. Do not use in food producing animals.
Dosage and Administration
Horses: 1.5 mg/kg every eight hours.
Mares ?¢‚Ǩ‚Äú Intra-uterine infusion ?¢‚Ǩ‚Äú 2.5 g, diluted in 400 mL sterile normal saline. Infuse daily for 3 - 5 days
during oestrus.
Give by sterile subcutaneous, intramuscular or intravenous injection.
Note: Veterinarians are referred to the chapter ?¢‚Ǩ?ìAntibiotics?¢‚Ǩ? by W. M. Pedersoli (1983. ?¢‚Ǩ?ìCurrent Therapy in
Equine Medicine?¢‚Ǩ?, Ed. Robinson, Pub. Saunders Co. pg 43 ?¢‚Ǩ‚Äú 57) for a comprehensive review of antibiotic
therapy in the horse and Gentamicin?¢‚Ǩ‚Ñ¢s place in it.
Presentation
100 mL sterile injectable solution, glass vial.
Storage
Store below 25o C (air conditioning). Protect from light.
Poisons Schedule
S4
APVMA Approval Number
55873
General Notes
Note: Veterinarians are referred to the chapter ?¢‚Ǩ?ìAntibiotics?¢‚Ǩ? by W. M. Pedersoli (1983. ?¢‚Ǩ?ìCurrent Therapy in Equine Medicine?¢‚Ǩ?, Ed. Robinson, Pub. Saunders Co. pg 43 ?¢‚Ǩ‚Äú 57) for a comprehensive review of antibiotic therapy in the horse and Gentamicin?¢‚Ǩ‚Ñ¢s place in it.
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